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A careful review of this data reveals that there is substantial uncertainty regarding the health risks of different nanomaterials The data on ultrafine particles may not be applicable to synthetic nanomaterials, because ultrafine particles are neither a consistent size nor pure in chemical or structural composition Also, with regard to carbon nanotubes, the data are conflicting and potentially misleading Studies showing that carbon black particles are toxic do not necessarily prove the toxicity of carbon nanotubes because carbon black may include other organic and metallic substances besides carbon nanotubes Similarly, the Warsaw study does not necessarily prove that carbon nanotubes are not toxic The experiment involved giving a test group of pathogen-free guinea pigs an intratracheal instillation of 25 mg of carbon nanotubes in soot while the control group was given soot without carbon nanotubes Researchers reported no significant differences in the animals inflammatory reactions.

next test cycle. Captured lessons, whether documented by the test manager or a third-party company, must be reviewed at the end of the testing cycle, which may cause modifications to test plans, test strategies, automation approach, design and construction of future test cases, and the approach for resolving and closing defects. For large or global organizations implementing SAP in multiple sites with potentially different system integrators, it is important to communicate the lessons learned company-wide and to have them posted in a common repository such as a company-sponsored intranet. A company s methodology, whether created in-house or adopted from another body, needs to be aligned with the need to capture lessons learned.

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However, even if soot containing carbon nanotubes is not more toxic than soot without carbon nanotubes, this does not prove that carbon nanotubes are not toxic Finally, the inconsistent results observed in the DuPont study have caused Warheit and his coworkers to question the physiological relevance of their findings42 In addition, the epidemiological data are not reliable Because personal exposure is seldom determined with any accuracy, it is difficult to establish a conclusive link between ultrafine particles and death43 Additionally, although the results demonstrate that ultrafine particles are associated with human deaths, the relative apportionment of causation between ultrafine particles and fine particle mass is not clear Finally, attempts to determine timing of effect by using the best lag approach can bias the results toward finding positive or negative statistically significant associations.

44 Further, data concerning the toxic effects of nanomaterials on animals may not be a reliable indicator of the toxic effects of nanomaterials on humans While the studies involve subjecting animals to a single chemical substance, people are exposed to a wide variety of different compounds at the same time Synergistic effects can compound the toxicity of a substance by 1,000 times45 Additionally, because test animals are genetically similar and usually healthy, young adults, they will often respond to the same substances in the same way46 By contrast, because people are genetically diverse, of different ages, and in different states of health, they will respond to the same substances differently47 Fundamental differences in human biology and animal biology result in substances having different effects on each.

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Effective income tax rate Ahold s effective tax rates in the consolidated statements of operations differ from the statutory income tax rates of the Netherlands, which were 29.6 percent, 31.5 percent and 34.5 percent for 2006, 2005 and 2004, respectively. The following table reconciles the statutory income tax rate of the Netherlands with the effective income tax rates as shown in the consolidated statements of operations:

48 For example, whereas animal tests show that betanapthylamine is relatively harmless, use of the substance in the workplace reveals that workers who have been exposed to it over a five-year period have a 100% bladder cancer rate49 Similarly, years of asbestos studies on animals beginning in the 1930s produced no evidence of risk50.

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